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CRRD ID: 621032
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDbisphenol A affects the expression of NR0B2 mRNA

affects methylationISORGD:7328746480464CTDbisphenol A affects the methylation of NR0B2 promoter

multiple interactionsISORGD:7328736480464CTD[bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NR0B2 protein modified form], bisphenol A affects the reaction [ESR1 protein binds to NR0B2 protein]

PMID:28751236, PMID:29389661
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.