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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730858
Species: Homo sapiens
CRRD Object: Gene
Symbol: IL2
Name: interleukin 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDbisphenol A affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein]

PMID:29777833
decreases expressionISORGD:6200476480464CTDbisphenol A results in decreased expression of IL2 mRNA

PMID:18569609, PMID:19267065
increases expressionISORGD:7333156480464CTDbisphenol A results in increased expression of IL2 mRNA

PMID:26063408
multiple interactionsISORGD:7333156480464CTDbisphenol A promotes the reaction [Lipopolysaccharides results in increased secretion of IL2 protein]

PMID:24189131
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.