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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 731380
Species: Homo sapiens
CRRD Object: Gene
Symbol: AIFM1
Name: apoptosis inducing factor mitochondria associated 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDbisphenol A affects the expression of AIFM1 mRNA

PMID:21826169
affects localizationISORGD:6208176480464CTDbisphenol A affects the localization of AIFM1 protein

PMID:25461564, PMID:27189055
increases expressionISORGD:6208176480464CTDbisphenol A results in increased expression of AIFM1 mRNA

PMID:25181051, PMID:25461564
multiple interactionsISORGD:6208176480464CTDAcetylcysteine inhibits the reaction [bisphenol A affects the localization of AIFM1 protein]

PMID:27189055
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.