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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 733535
Species: Mus musculus
CRRD Object: Gene
Symbol: Pde9a
Name: phosphodiesterase 9A
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects methylationISORGD:6210356480464CTDbisphenol A affects the methylation of PDE9A promoter

PMID:27415467
decreases expressionISORGD:6210356480464CTDbisphenol A results in decreased expression of PDE9A mRNA

PMID:25181051, PMID:29097150
increases methylationISORGD:6210356480464CTDbisphenol A results in increased methylation of PDE9A gene

PMID:28505145
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.