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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 737494
Species: Homo sapiens
CRRD Object: Gene
Symbol: SYP
Name: synaptophysin
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:113736480464CTDbisphenol A results in decreased expression of SYP protein

PMID:28089772
decreases expressionISORGD:38026480464CTDbisphenol A results in decreased expression of SYP mRNA, bisphenol A results in decreased expression of SYP protein

PMID:24820113, PMID:25181051
increases expressionISORGD:113736480464CTDbisphenol A results in increased expression of SYP protein

PMID:22981971
increases methylationISORGD:38026480464CTDbisphenol A results in increased methylation of SYP gene

PMID:28505145
multiple interactionsISORGD:38026480464CTD[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of SYP mRNA

PMID:25607892
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.