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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1308611
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Slc19a2
Name: solute carrier family 19 member 2
Acc ID: CHEBI:33283
Term: thiamine(1+) chloride
Definition: A thiamine that has formula C12H17ClN4OS.
Chemical ID: MESH:D013831
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13184846480464CTDThiamine deficiency results in increased expression of SLC19A2 mRNA, Thiamine deficiency results in increased expression of SLC19A2 protein

PMID:16705148
increases uptakeISORGD:13184846480464CTDSLC19A2 protein results in increased uptake of Thiamine

PMID:16705148
increases uptakeISORGD:13184856480464CTDSLC19A2 protein results in increased uptake of Thiamine

PMID:24244374
multiple interactionsISORGD:13184856480464CTD[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of SLC19A2 protein] which results in decreased uptake of Thiamine

PMID:24244374
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.