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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1560955
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ndufa1
Name: NADH:ubiquinone oxidoreductase subunit A1
Acc ID: CHEBI:34107
Term: 1-nitropyrene
Definition: A nitroarene that is pyrene substituted at the 1-position by a nitro group. A by-product of combustion, it is the predominant nitrated polycyclic aromatic hydrocarbon emitted in a diesel engine.
Chemical ID: MESH:C032668
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13504976480464CTD1-nitropyrene results in decreased expression of NDUFA1 mRNA

PMID:29078374
decreases expressionISORGD:16151426480464CTD1-nitropyrene results in decreased expression of NDUFA1 mRNA, 1-nitropyrene results in decreased expression of NDUFA1 protein

PMID:29078374
multiple interactionsISORGD:13504976480464CTD[Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA1 mRNA], NDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA], NDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]

PMID:29078374
multiple interactionsISORGD:16151426480464CTD[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA1 mRNA]

PMID:29078374
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.