GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2466
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp2b1
Name: cytochrome P450, family 2, subfamily b, polypeptide 1
Acc ID: CHEBI:34199
Term: 2,2',3,3',6,6'-hexachlorobiphenyl
Definition: A hexachlorobiphenyl that has formula C12H4Cl6.
Chemical ID: MESH:C010498
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases oxidationEXP 6480464CTDCYP2B1 protein results in increased oxidation of 2,3,6,2',3',6'-hexachlorobiphenyl

PMID:22026639
decreases expressionISOCRRD:15583116480464CTD2,3,6,2',3',6'-hexachlorobiphenyl results in decreased expression of CYP2B10 protein

PMID:28431184
increases expressionISOCRRD:15583116480464CTD2,3,6,2',3',6'-hexachlorobiphenyl results in increased expression of CYP2B10 protein

PMID:28431184
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.