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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61856
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Gabra2
Name: gamma-aminobutyric acid type A receptor alpha2 subunit
Acc ID: CHEBI:3423
Term: carmustine
Definition: A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
Chemical ID: MESH:D002330
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceISOCRRD:13494866480464CTDGABRA2 mRNA affects the susceptibility to Carmustine

PMID:16365179
decreases expressionISOCRRD:13494866480464CTDCarmustine results in decreased expression of GABRA2 mRNA

PMID:15980968
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.