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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 70913
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Abcc5
Name: ATP binding cassette subfamily C member 5
Acc ID: CHEBI:34317
Term: 3,3',4,4',5-pentachlorobiphenyl
Definition: A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.
Chemical ID: MESH:C023035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTD3, 4, 5, 3', 4'-pentachlorobiphenyl results in decreased expression of ABCC5 mRNA

PMID:16260000, PMID:23196670
increases expressionISORGD:7374646480464CTD3, 4, 5, 3', 4'-pentachlorobiphenyl results in increased expression of ABCC5 mRNA

PMID:15833929
multiple interactionsISORGD:7374646480464CTD[3, 4, 5, 3', 4'-pentachlorobiphenyl binds to AHR protein] which results in increased expression of ABCC5 mRNA

PMID:15833929
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.