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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1583832
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Pgd
Name: phosphogluconate dehydrogenase
Acc ID: CHEBI:3441
Term: carvedilol
Definition: A member of the class of carbazoles that is an adrenergic antagonist with non-selective beta- and alpha-1 receptor blocking properties which helps in the management of congestive heart failure.
Chemical ID: MESH:C043211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDcarvedilol inhibits the reaction [Norepinephrine results in increased activity of PGD mRNA], carvedilol inhibits the reaction [Norepinephrine results in increased activity of PGD protein]

PMID:1378361
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.