GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2459
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:34569
Term: Benzo[k]fluoranthene
Definition: A naphthalene that has formula C20H12.
Chemical ID: MESH:C022921
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISOCRRD:7357116480464CTDbenzo(k)fluoranthene results in decreased activity of CYP1A2 protein

PMID:11162773
increases expressionISOCRRD:7357116480464CTDbenzo(k)fluoranthene results in increased expression of CYP1A2 mRNA

benzo(k)fluoranthene results in increased expression of CYP1A2 protein

PMID:11162773, PMID:11370663, PMID:17253728
multiple interactionsISOCRRD:104386480464CTD[fluoranthene co-treated with pyrene co-treated with benz(a)anthracene co-treated with chrysene co-treated with benzo(b)fluoranthene co-treated with benzo(k)fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of CYP1A2 mRNA

PMID:7750161
multiple interactionsISOCRRD:7357116480464CTDsodium arsenite inhibits the reaction [benzo(k)fluoranthene results in increased expression of CYP1A2 mRNA]

sodium arsenite inhibits the reaction [benzo(k)fluoranthene results in increased expression of CYP1A2 protein]

PMID:11162773
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.