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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620575
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Apaf1
Name: apoptotic peptidase activating factor 1
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7332946480464CTDChlorpyrifos results in decreased expression of APAF1 mRNA

PMID:20350560
increases expressionISORGD:7332936480464CTDChlorpyrifos results in increased expression of APAF1 protein

PMID:26435000
increases expressionISORGD:7332946480464CTDChlorpyrifos results in increased expression of APAF1 mRNA

PMID:27737797
multiple interactionsISORGD:7332936480464CTDMitoTEMPO inhibits the reaction [Chlorpyrifos results in increased expression of APAF1 protein]

PMID:26435000
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.