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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2466
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp2b1
Name: cytochrome P450, family 2, subfamily b, polypeptide 1
Acc ID: CHEBI:34674
Term: dextran sulfate
Definition: A polymer composed of repeating (1->6)-alpha-linked anhydroglucose sulfate units.
Chemical ID: MESH:D016264
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDDextran Sulfate results in decreased activity of CYP2B1 protein

PMID:28438436
multiple interactionsEXP 6480464CTD[Dextran Sulfate results in decreased activity of CYP2B1 protein] which results in decreased chemical synthesis of hydroxybupropion

PMID:28438436
multiple interactionsISORGD:15583116480464CTD[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of CYP2B10 mRNA

PMID:29950665
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.