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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2835
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Hsd11b2
Name: hydroxysteroid 11-beta dehydrogenase 2
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDDibutyl Phthalate results in decreased activity of HSD11B2 protein

PMID:19786001
decreases expressionEXP 6480464CTDDibutyl Phthalate results in decreased expression of HSD11B2 mRNA

PMID:19560483, PMID:21266533
decreases activityISORGD:7374686480464CTDDibutyl Phthalate results in decreased activity of HSD11B2 protein

PMID:19786001
decreases expressionISORGD:107356480464CTDDibutyl Phthalate results in decreased expression of HSD11B2 mRNA

PMID:17361019, PMID:21266533
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.