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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1323510
Species: Mus musculus
CRRD Object: Gene
Symbol: Akr1c21
Name: aldo-keto reductase family 1, member C21
Acc ID: CHEBI:34718
Term: 1-chloro-2,4-dinitrobenzene
Definition: A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.
Chemical ID: MESH:D004137
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISORGD:13539016480464CTDDinitrochlorobenzene results in increased activity of AKR1C2 promoter

PMID:21195160
increases expressionISORGD:13539016480464CTDDinitrochlorobenzene results in increased expression of AKR1C2 mRNA

PMID:20491607, PMID:20713136
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.