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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730927
Species: Homo sapiens
CRRD Object: Gene
Symbol: IL5
Name: interleukin 5
Acc ID: CHEBI:34718
Term: 1-chloro-2,4-dinitrobenzene
Definition: A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.
Chemical ID: MESH:D004137
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:107996480464CTDDinitrochlorobenzene results in increased expression of IL5 mRNA

PMID:23133493, PMID:23200891, PMID:23454147
multiple interactionsISORGD:107996480464CTD[Antigens, Dermatophagoides co-treated with Dinitrochlorobenzene] results in increased expression of IL5 mRNA, Biological Products inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL5 mRNA], oleanolic acid 3-acetate inhibits the reaction [[Antigens, Dermatophagoides co-treated with Dinitrochlorobenzene] results in increased expression of IL5 mRNA], Plant Extracts inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL5 mRNA], Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL5 mRNA]

PMID:23133493, PMID:23200891, PMID:23454147, PMID:23499868
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.