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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3351
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Plin1
Name: perilipin 1
Acc ID: CHEBI:34795
Term: 3-isobutyl-1-methyl-7H-xanthine
Definition: A 3-isobutyl-1-methylxanthine that has formula C10H14N4O2.
Chemical ID: MESH:D015056
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7334826480464CTD[1-Methyl-3-isobutylxanthine co-treated with troglitazone co-treated with INS protein] results in increased expression of PLIN1 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PLIN1 mRNA

PMID:27003841, PMID:28628672
multiple interactionsISORGD:7362206480464CTD[1-Methyl-3-isobutylxanthine co-treated with bisphenol A co-treated with INS protein] results in increased expression of PLIN1 protein, [1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased expression of PLIN1 protein, [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PLIN1 mRNA, [bis(4-hydroxyphenyl)sulfone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of PLIN1 mRNA, [bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of PLIN1 mRNA, [licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PLIN1 mRNA, [licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PLIN1 protein, [PRKACA protein affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PLIN1 mRNA, [PRKACA protein affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PLIN1 protein, [Rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in decreased expression of PLIN1 mRNA, N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PLIN1 protein], PRKACA protein promotes the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PLIN1 protein]

PMID:23428407, PMID:26820058, PMID:27273607, PMID:29288687
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.