GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69057
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:34848
Term: mevastatin
Definition: A carboxylic ester that is pravastatin that is lacking the allylic hydroxy group. A hydroxymethylglutaryl-CoA reductase inhibitor (statin) isolated from Penicillium citrinum and from Penicillium brevicompactum, its clinical use as a lipid-regulating drug ceased following reports of toxicity in animals.
Chemical ID: MESH:C012258
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISOCRRD:691056480464CTD[mevastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA

NR1I2 protein promotes the reaction [mevastatin results in increased expression of CYP3A4 mRNA]

PMID:12235278, PMID:17041008
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.