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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621821
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Fen1
Name: flap structure-specific endonuclease 1
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDDiethylnitrosamine results in increased expression of FEN1 mRNA

PMID:19041683
increases expressionISORGD:7326806480464CTDDiethylnitrosamine results in increased expression of FEN1 mRNA

PMID:17854601
multiple interactionsISORGD:7326806480464CTDRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of FEN1 mRNA]

PMID:17854601
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.