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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 628635
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Akr7a3
Name: aldo-keto reductase family 7 member A3
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDDiethylnitrosamine results in decreased expression of AKR7A3 mRNA

PMID:11323195
increases expressionEXP 6480464CTDDiethylnitrosamine results in increased expression of AKR7A3 mRNA

PMID:19638242, PMID:21813463
multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of AKR7A3 mRNA, [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of AKR7A3 mRNA, [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of AKR7A3 mRNA, [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of AKR7A3 mRNA, [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of AKR7A3 mRNA, [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of AKR7A3 mRNA, [Omeprazole co-treated with Diethylnitrosamine] results in increased expression of AKR7A3 mRNA, [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of AKR7A3 mRNA, Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of AKR7A3 mRNA]

PMID:18164116, PMID:18754104, PMID:20033131, PMID:22129741, PMID:22467020, PMID:22687989, PMID:28943392
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.