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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 736685
Species: Homo sapiens
CRRD Object: Gene
Symbol: HSBP1
Name: heat shock factor binding protein 1
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7366866480464CTDDiethylnitrosamine results in increased expression of HSBP1 protein

PMID:18691550
multiple interactionsISORGD:7366866480464CTDHSBP1 protein inhibits the reaction [Diethylnitrosamine results in increased abundance of Reactive Oxygen Species], MAPK14 protein promotes the reaction [Diethylnitrosamine results in increased expression of HSBP1 mRNA], MAPK14 protein promotes the reaction [Diethylnitrosamine results in increased expression of HSBP1 protein]

PMID:18691550
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.