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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3286
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Pdha1
Name: pyruvate dehydrogenase E1 alpha 1 subunit
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7365576480464CTD[Maneb co-treated with Paraquat] results in decreased expression of PDHA1 mRNA, [Maneb co-treated with Paraquat] results in increased expression of PDHA1 protein, Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PDHA1 protein], Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PDHA1 mRNA]

PMID:23562983, PMID:23963992
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