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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61312
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDParaquat affects the expression of TIMP2 mRNA

PMID:16854511
multiple interactionsEXP 6480464CTDAmbroxol affects the reaction [Paraquat results in increased expression of TIMP2 mRNA]

PMID:21921364
decreases expressionISORGD:621786480464CTDParaquat results in decreased expression of TIMP2 mRNA, Paraquat results in decreased expression of TIMP2 protein

PMID:17215068, PMID:26988026
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.