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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 733705
Species: Homo sapiens
CRRD Object: Gene
Symbol: CTNNB1
Name: catenin beta 1
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects localizationEXP 6480464CTDParaquat affects the localization of CTNNB1 protein

PMID:30205152
multiple interactionsEXP 6480464CTDLGK974 inhibits the reaction [Paraquat affects the localization of CTNNB1 protein], LGK974 inhibits the reaction [Paraquat results in increased expression of and results in decreased phosphorylation of CTNNB1 protein], Paraquat results in increased expression of and results in decreased phosphorylation of CTNNB1 protein, WNT1 protein inhibits the reaction [Paraquat results in decreased expression of CTNNB1 mRNA], WNT1 protein inhibits the reaction [Paraquat results in decreased expression of CTNNB1 protein]

PMID:30171970, PMID:30205152
decreases expressionISORGD:15504666480464CTDParaquat results in decreased expression of CTNNB1 mRNA, Paraquat results in decreased expression of CTNNB1 protein

PMID:27788593, PMID:30171970
decreases expressionISORGD:704876480464CTDParaquat results in decreased expression of CTNNB1 mRNA

PMID:26887261
decreases response to substanceISORGD:15504666480464CTDCTNNB1 protein results in decreased susceptibility to Paraquat

PMID:23620592
multiple interactionsISORGD:15504666480464CTDCTNNB1 protein inhibits the reaction [Paraquat results in increased abundance of Reactive Oxygen Species], Lithium Chloride inhibits the reaction [Paraquat results in decreased expression of CTNNB1 protein], Paraquat inhibits the reaction [CTNNB1 protein binds to MPZ promoter], Paraquat inhibits the reaction [CTNNB1 protein binds to PMP22 promoter]

PMID:23620592, PMID:27788593, PMID:30171970
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.