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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 737414
Species: Mus musculus
CRRD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:692796480464CTDParaquat results in decreased expression of CDH1 mRNA, Paraquat results in decreased expression of CDH1 protein

PMID:25873302, PMID:28624451, PMID:30403199
multiple interactionsISORGD:692796480464CTDAnthocyanins inhibits the reaction [Paraquat results in decreased expression of CDH1 protein], NFE2L2 protein promotes the reaction [Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]], Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 mRNA], Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 protein], sulforafan inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]

PMID:28624451, PMID:30403199
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.