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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 731380
Species: Homo sapiens
CRRD Object: Gene
Symbol: AIFM1
Name: apoptosis inducing factor mitochondria associated 1
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects localizationISORGD:6208176480464CTDCadmium Chloride affects the localization of AIFM1 protein

PMID:16597613
affects localizationISORGD:7313816480464CTDCadmium Chloride affects the localization of AIFM1 protein

PMID:18506790, PMID:19887573
increases expressionISORGD:6208176480464CTDCadmium Chloride results in increased expression of AIFM1 protein

PMID:28457857
increases secretionISORGD:6208176480464CTDCadmium Chloride results in increased secretion of AIFM1 protein

PMID:16809017
multiple interactionsISORGD:7313816480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride affects the localization of AIFM1 protein], Cyclosporine inhibits the reaction [Cadmium Chloride affects the localization of AIFM1 protein], KN 93 inhibits the reaction [Cadmium Chloride affects the localization of AIFM1 protein], SB 203580 inhibits the reaction [Cadmium Chloride affects the localization of AIFM1 protein]

PMID:18506790
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.