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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 70999
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Decr1
Name: 2,4-dienoyl-CoA reductase 1
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDperfluorooctanoic acid results in increased expression of DECR1 mRNA

PMID:16221955, PMID:19162173, PMID:28511854
affects expressionISORGD:7363776480464CTDperfluorooctanoic acid affects the expression of DECR1 mRNA

PMID:18281256, PMID:19429403
increases expressionISORGD:7336056480464CTDperfluorooctanoic acid results in increased expression of DECR1 protein

PMID:26879310
increases expressionISORGD:7363776480464CTDperfluorooctanoic acid results in increased expression of DECR1 mRNA

PMID:23626681, PMID:28558994, PMID:30711707
multiple interactionsISORGD:7363776480464CTDDietary Fats, Unsaturated promotes the reaction [perfluorooctanoic acid results in increased expression of DECR1 mRNA]

PMID:23626681
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.