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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 11250
Species: Mus musculus
CRRD Object: Gene
Symbol: Rxra
Name: retinoid X receptor alpha
Acc ID: CHEBI:35591
Term: pregnenolone 16alpha-carbonitrile
Definition: An aliphatic nitrile that has formula C22H31NO2.
Chemical ID: MESH:D011285
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Pregnenolone Carbonitrile promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]] which results in increased expression of SULT2A1 mRNA, Pregnenolone Carbonitrile promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]

PMID:12370413
multiple interactionsISORGD:36106480464CTD[Pregnenolone Carbonitrile promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]] which results in increased expression of SULT2A1 mRNA, Pregnenolone Carbonitrile promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to CYP3A23/3A1 promoter], Pregnenolone Carbonitrile promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]

PMID:12370413
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.