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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61312
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:35807
Term: N-nitrosodimethylamine
Definition: A nitrosamine that has formula C2H6N2O.
Chemical ID: MESH:D004128
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDDimethylnitrosamine affects the expression of TIMP2 mRNA

PMID:16042886
increases activityEXP 6480464CTDDimethylnitrosamine results in increased activity of TIMP2 protein

PMID:15161499
increases expressionEXP 6480464CTDDimethylnitrosamine results in increased expression of TIMP2 mRNA, Dimethylnitrosamine results in increased expression of TIMP2 protein

PMID:16965748, PMID:17036385, PMID:17348192, PMID:18371158, PMID:25380136
multiple interactionsEXP 6480464CTDDrugs, Chinese Herbal inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP2 mRNA], Drugs, Chinese Herbal inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP2 protein], Plant Preparations inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP2 protein]

PMID:16965748, PMID:17036385, PMID:17348192, PMID:18371158
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.