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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61312
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:35828
Term: arsenic(3+)
Definition: A monoatomic arsenic that has formula As.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:7339066480464CTDArsenic affects the expression of TIMP2 protein

PMID:24675094
affects methylationISORGD:7339066480464CTDArsenic affects the methylation of TIMP2 gene

PMID:25304211
decreases expressionISORGD:621786480464CTDArsenic results in decreased expression of TIMP2 mRNA

PMID:19654921
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.