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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3363
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Polb
Name: DNA polymerase beta
Acc ID: CHEBI:35852
Term: transplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a trans planar configuration around the central platinum ion. Unlike its cis-isomer, cisplatin, it does not exhibit any useful pharmacological effect and is toxic.
Chemical ID: MESH:C034697
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases response to substanceISORGD:7366096480464CTDPOLB results in decreased susceptibility to transplatin

PMID:21357694
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