GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621511
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ctsd
Name: cathepsin D
Acc ID: CHEBI:3638
Term: chloroquine
Definition: An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Chemical ID: MESH:D002738
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects localizationEXP 6480464CTDChloroquine affects the localization of CTSD protein

PMID:7715800
increases expressionEXP 6480464CTDChloroquine results in increased expression of CTSD protein

PMID:2759144
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.