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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 737414
Species: Mus musculus
CRRD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:3638
Term: chloroquine
Definition: An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Chemical ID: MESH:D002738
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:692796480464CTDChloroquine inhibits the reaction [Dibutyl Phthalate results in decreased expression of CDH1 mRNA], Chloroquine inhibits the reaction [Dibutyl Phthalate results in decreased expression of CDH1 protein]

PMID:30053495
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.