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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 619573
Species: Mus musculus
CRRD Object: Gene
Symbol: Slc22a6
Name: solute carrier family 22 (organic anion transporter), member 6
Acc ID: CHEBI:3699
Term: cimetidine
Definition: A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Chemical ID: MESH:D002927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a6increases uptakeISORGD:6195726480464CTDSLC22A6 protein results in increased uptake of Cimetidine

PMID:15496291, PMID:16006492, PMID:16098483
Slc22a6multiple interactionsISORGD:6195726480464CTD1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A6 protein results in increased uptake of Cimetidine], Cimetidine inhibits the reaction [SLC22A6 protein affects the transport of p-Aminohippuric Acid], p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of Cimetidine]

PMID:15496291
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.