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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1319092
Species: Homo sapiens
CRRD Object: Gene
Symbol: NTS
Name: neurotensin
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted to the corresponding acetate and myristate esters.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDTetradecanoylphorbol Acetate results in decreased activity of NTS protein

PMID:18313772
multiple interactionsEXP 6480464CTD2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein], bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein], Go 6976 inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein], Okadaic Acid promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein], Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein], Sucrose promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein], Tetradecanoylphorbol Acetate inhibits the reaction [2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide results in increased activity of NTS protein], Tetradecanoylphorbol Acetate inhibits the reaction [Go 6976 results in increased activity of NTS protein], Tetradecanoylphorbol Acetate inhibits the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates], Tetradecanoylphorbol Acetate inhibits the reaction [Ro 31-8220 results in increased activity of NTS protein], Tetradecanoylphorbol Acetate inhibits the reaction [Staurosporine results in increased activity of NTS protein]

PMID:18313772
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.