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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730881
Species: Homo sapiens
CRRD Object: Gene
Symbol: HRAS
Name: HRas proto-oncogene, GTPase
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted to the corresponding acetate and myristate esters.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Tetradecanoylphorbol Acetate co-treated with arsenic trioxide] results in increased expression of HRAS mRNA, HRAS protein affects the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of CDH5 protein]

PMID:18922899, PMID:24211779
increases expressionISORGD:107306480464CTDTetradecanoylphorbol Acetate results in increased expression of HRAS mRNA

PMID:17106253
multiple interactionsISORGD:107306480464CTD[9, 10-Dimethyl-1, 2-benzanthracene co-treated with Tetradecanoylphorbol Acetate co-treated with mezerein] results in increased expression of HRAS mRNA, [9, 10-Dimethyl-1, 2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of HRAS mRNA, [9, 10-Dimethyl-1, 2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in increased mutagenesis of HRAS gene, [Benzo(a)pyrene co-treated with Tetradecanoylphorbol Acetate] affects the mutagenesis of HRAS gene, [Tetradecanoylphorbol Acetate co-treated with 9, 10-Dimethyl-1, 2-benzanthracene co-treated with geraniol] affects the localization of HRAS protein, [Tetradecanoylphorbol Acetate co-treated with 9, 10-Dimethyl-1, 2-benzanthracene] results in increased expression of HRAS protein, [Zidovudine co-treated with Tetradecanoylphorbol Acetate] results in increased mutagenesis of HRAS gene, bicyclol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HRAS mRNA]

PMID:11241758, PMID:11765016, PMID:17106253, PMID:22760862, PMID:3115617, PMID:9766437
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.