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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 737062
Species: Homo sapiens
CRRD Object: Gene
Symbol: PRKCA
Name: protein kinase C alpha
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted to the corresponding acetate and myristate esters.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects localizationEXP 6480464CTDTetradecanoylphorbol Acetate affects the localization of PRKCA protein

PMID:15976015, PMID:19447859, PMID:20032081, PMID:20152819, PMID:21705328, PMID:25866363, PMID:30133131, PMID:9852137
decreases expressionEXP 6480464CTDTetradecanoylphorbol Acetate results in decreased expression of PRKCA protein

PMID:15330761, PMID:17171646, PMID:18313772
decreases phosphorylationEXP 6480464CTDTetradecanoylphorbol Acetate results in decreased phosphorylation of PRKCA protein

PMID:15380616
increases activityEXP 6480464CTDTetradecanoylphorbol Acetate results in increased activity of PRKCA protein

PMID:21705328
increases expressionEXP 6480464CTDTetradecanoylphorbol Acetate results in increased expression of PRKCA protein modified form

PMID:16532021
increases phosphorylationEXP 6480464CTDTetradecanoylphorbol Acetate results in increased phosphorylation of PRKCA protein

PMID:20152819, PMID:20590612, PMID:24672638
multiple interactionsEXP 6480464CTD[Ethanol results in increased localization of and results in increased activity of PRKCA protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides], [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein] which results in increased expression of SOD2, calphostin C inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein], dihydroartemisinin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein], dihydroartemisinin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCA protein], Luteolin analog inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein], Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCA protein], naringenin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein], piperine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and affects the localization of PRKCA protein], PRKCA protein affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 mRNA], Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of and results in increased phosphorylation of and results in increased activity of PRKCA protein], Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCA protein], Rosiglitazone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein], Tetradecanoylphorbol Acetate affects the localization of and results in increased activity of PRKCA protein, Tetradecanoylphorbol Acetate results in increased activity of and affects the localization of PRKCA protein, Tetradecanoylphorbol Acetate results in increased localization of and results in increased phosphorylation of and results in increased activity of PRKCA protein, Tetradecanoylphorbol Acetate results in increased phosphorylation of and affects the localization of PRKCA protein

PMID:10651808, PMID:14739659, PMID:15978937, PMID:16091123, PMID:19394402, PMID:20032081, PMID:20152819, PMID:20590612, PMID:21354279, PMID:21705328, PMID:24672638, PMID:25866363, PMID:30133131
affects localizationISORGD:33956480464CTDTetradecanoylphorbol Acetate affects the localization of PRKCA protein

PMID:12720544, PMID:14678745, PMID:14736339, PMID:14975926
affects localizationISORGD:7370636480464CTDTetradecanoylphorbol Acetate affects the localization of PRKCA protein

PMID:16343552
decreases expressionISORGD:33956480464CTDTetradecanoylphorbol Acetate results in decreased expression of PRKCA protein

PMID:12590138
increases activityISORGD:7370636480464CTDTetradecanoylphorbol Acetate results in increased activity of PRKCA protein

PMID:20172950
increases expressionISORGD:7370636480464CTDTetradecanoylphorbol Acetate results in increased expression of PRKCA mRNA

PMID:17106253
increases localizationISORGD:7370636480464CTDTetradecanoylphorbol Acetate results in increased localization of PRKCA protein

PMID:10656618
multiple interactionsISORGD:33956480464CTD1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein], calphostin C inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein], Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein], Tetradecanoylphorbol Acetate affects the localization of and results in increased activity of PRKCA protein

PMID:12590138, PMID:14678745
multiple interactionsISORGD:7370636480464CTD4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein], bicyclol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PRKCA mRNA], bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein], calphostin C inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein], Egtazic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein], PRKCA protein promotes the reaction [[Tetradecanoylphorbol Acetate results in increased expression of and results in increased phosphorylation of STAR protein] which results in increased abundance of Progesterone], PRKCA protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAR mRNA], PRKCA protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAR protein], Tetradecanoylphorbol Acetate binds to and affects the localization of PRKCA protein, Tetradecanoylphorbol Acetate results in increased activity of and results in increased localization of PRKCA protein, Tetradecanoylphorbol Acetate results in increased expression of and results in increased phosphorylation of PRKCA protein, TGFB1 affects the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein], TGFB1 promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein]

PMID:16099101, PMID:16343552, PMID:17106253, PMID:20172950, PMID:21047949, PMID:22020176
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.