GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2522
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Drd4
Name: dopamine receptor D4
Acc ID: CHEBI:3766
Term: clozapine
Definition: A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.
Chemical ID: MESH:D003024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTDClozapine analog binds to DRD4 protein

PMID:11997696
affects bindingISOCRRD:7361386480464CTDClozapine binds to DRD4 protein

PMID:11997696
affects response to substanceISOCRRD:7361386480464CTDDRD4 gene polymorphism affects the susceptibility to Clozapine

PMID:16223700
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.