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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61800
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Htr2a
Name: 5-hydroxytryptamine receptor 2A
Acc ID: CHEBI:3766
Term: clozapine
Definition: A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.
Chemical ID: MESH:D003024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTDClozapine binds to HTR2A protein

PMID:9723970
decreases activityEXP 6480464CTDClozapine results in decreased activity of HTR2A protein

PMID:15380371
decreases expressionEXP 6480464CTDClozapine results in decreased expression of HTR2A mRNA

Clozapine results in decreased expression of HTR2A protein

PMID:14751426, PMID:17868938
multiple interactionsEXP 6480464CTD[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein

[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein

alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]

Clozapine binds to and results in decreased activity of HTR2A protein

Clozapine promotes the reaction [Phencyclidine results in decreased activity of HTR2A protein]

PMID:15380371, PMID:18976543
affects bindingISOCRRD:7341076480464CTDClozapine analog binds to HTR2A protein

Clozapine binds to HTR2A protein

PMID:11997696, PMID:16983399, PMID:7520908
affects response to substanceISOCRRD:7341076480464CTDHTR2A protein affects the susceptibility to Clozapine

PMID:16314884
increases expressionISOCRRD:620926480464CTDClozapine results in increased expression of HTR2A mRNA

PMID:15542763
increases response to substanceISOCRRD:7341076480464CTDHTR2A gene SNP results in increased susceptibility to Clozapine

PMID:16314884
multiple interactionsISOCRRD:7341076480464CTDClozapine binds to and results in decreased activity of HTR2A protein

Clozapine inhibits the reaction [Ketanserin binds to HTR2A protein]

PMID:16314884, PMID:20521326
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.