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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1615939
Species: Mus musculus
CRRD Object: Gene
Symbol: Thbs1
Name: thrombospondin 1
Acc ID: CHEBI:37941
Term: clopidogrel
Definition: A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group, the methylene hydrogen of which is replaced by a methoxycarbonyl group (the S enantiomer). A P2Y12 receptor antagonist, it is used to inhibit blood clots and prevent heart attacks.
Chemical ID: MESH:C055162
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13459426480464CTDclopidogrel results in increased expression of THBS1, clopidogrel results in increased expression of THBS1 mRNA, clopidogrel results in increased expression of THBS1 protein

PMID:11875746, PMID:9447704
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.