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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1347196
Species: Homo sapiens
CRRD Object: Gene
Symbol: UXT
Name: ubiquitously expressed prefoldin like chaperone
Acc ID: CHEBI:379896
Term: 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one
Definition: A synthetic non-aromatisable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors.
Chemical ID: MESH:D015741
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceEXP 6480464CTDUXT protein affects the susceptibility to Metribolone

PMID:19318562
multiple interactionsEXP 6480464CTDMetribolone promotes the reaction [UXT protein binds to ATR promoter], Metribolone promotes the reaction [UXT protein binds to GSTE1 promoter], Metribolone promotes the reaction [UXT protein binds to KLK3 promoter], Metribolone promotes the reaction [UXT protein binds to NKX3-1 promoter], UXT protein affects the reaction [Metribolone results in increased expression of BRIP1 mRNA], UXT protein affects the reaction [Metribolone results in increased expression of KLK3 mRNA], UXT protein affects the reaction [Metribolone results in increased expression of NKX3-1 mRNA]

PMID:19318562
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.