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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1323510
Species: Mus musculus
CRRD Object: Gene
Symbol: Akr1c21
Name: aldo-keto reductase family 1, member C21
Acc ID: CHEBI:38746
Term: parathion-methyl
Definition: A C-nitro compound that is 4-nitrophenol substituted by a (dimethoxyphosphorothioyl)oxy group at position 4.
Chemical ID: MESH:D008743
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISORGD:13539016480464CTDMethyl Parathion results in increased activity of AKR1C2 protein

PMID:19800895
increases expressionISORGD:13539016480464CTDMethyl Parathion results in increased expression of AKR1C2 mRNA

PMID:19800895
multiple interactionsISORGD:13539016480464CTDAKR1C2 protein affects the susceptibility to [Benzo(a)pyrene co-treated with Methyl Parathion], Benzo(a)pyrene promotes the reaction [Methyl Parathion results in increased activity of AKR1C2 protein], Methyl Parathion promotes the reaction [Benzo(a)pyrene results in increased expression of AKR1C2 mRNA]

PMID:19800895
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.