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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1583909
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Dhrs2
Name: dehydrogenase/reductase 2
Acc ID: CHEBI:3908
Term: coumestrol
Definition: A member of the class of coumestans that is coumestan with hydroxy substituents at positions 3 and 9.
Chemical ID: MESH:D003375
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13217746480464CTDCoumestrol results in increased expression of DHRS2 mRNA

PMID:19167446
multiple interactionsISORGD:13217746480464CTD[Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of DHRS2 mRNA, [Coumestrol co-treated with ESR1 protein] results in increased expression of DHRS2 mRNA, [Coumestrol co-treated with resveratrol] results in increased expression of DHRS2 mRNA, ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of DHRS2 mRNA]

PMID:18310284, PMID:19167446
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.