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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2933
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Itpr1
Name: inositol 1,4,5-trisphosphate receptor, type 1
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in increased expression of ITPR1 mRNA

PMID:20136073
multiple interactionsISOCRRD:108216480464CTDperfluorooctane sulfonic acid inhibits the reaction [ITPR1 protein binds to HSPA9 protein binds to VDAC1 protein]

perfluorooctane sulfonic acid promotes the reaction [ITPR1 protein binds to AKT1 protein]

PMID:28288859
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.