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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1352527
Species: Homo sapiens
CRRD Object: Gene
Symbol: SMAD4
Name: SMAD family member 4
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:690926480464CTDCurcumin results in decreased expression of SMAD4 mRNA

PMID:27237783
multiple interactionsISORGD:30336480464CTDCurcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter]

PMID:16959952
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.