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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620575
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Apaf1
Name: apoptotic peptidase activating factor 1
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of APAF1 mRNA]

PMID:20869986
increases expressionISORGD:7332946480464CTDCurcumin results in increased expression of APAF1 protein

PMID:17277231
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.