GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 67383
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Prkcd
Name: protein kinase C, delta
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTDCurcumin binds to PRKCD protein

PMID:19161989
multiple interactionsEXP 6480464CTDCurcumin results in increased phosphorylation of and results in increased degradation of PRKCD protein

PMID:19161989
increases phosphorylationISOCRRD:690266480464CTDCurcumin results in increased phosphorylation of PRKCD protein

PMID:17171638
multiple interactionsISOCRRD:690266480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]

Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]

Buthionine Sulfoximine promotes the reaction [Curcumin results in increased phosphorylation of PRKCD protein]

Curcumin inhibits the reaction [PRKCD protein results in increased expression of IVL mRNA]

Glutathione inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]

PRKCD protein promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]

rottlerin inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]

Staurosporine inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]

wortmannin inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]

PMID:17148446, PMID:17171638
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.