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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69152
Species: Homo sapiens
CRRD Object: Gene
Symbol: EGFR
Name: epidermal growth factor receptor
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDCurcumin analog results in decreased expression of EGFR mRNA, Curcumin results in decreased expression of EGFR mRNA, Curcumin results in decreased expression of EGFR protein

PMID:15486348, PMID:17918158, PMID:18719366, PMID:26409325
decreases phosphorylationEXP 6480464CTDCurcumin results in decreased phosphorylation of EGFR protein

PMID:15486348
multiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [Acrylamide results in increased expression of EGFR protein], Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein], Curcumin promotes the reaction [Folfox protocol results in decreased expression of EGFR protein], Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of EGFR protein], Curcumin results in decreased expression of and results in decreased activity of EGFR protein, Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein, Fluorouracil promotes the reaction [Curcumin results in decreased expression of EGFR protein], Fluorouracil promotes the reaction [Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein]

PMID:10851300, PMID:15129424, PMID:17918158, PMID:18214481, PMID:24508477
decreases expressionISORGD:25436480464CTDCurcumin results in decreased expression of EGFR mRNA, Curcumin results in decreased expression of EGFR protein

PMID:18332871
decreases phosphorylationISORGD:25436480464CTDCurcumin results in decreased phosphorylation of EGFR protein

PMID:17372590, PMID:18332871
multiple interactionsISORGD:25436480464CTDCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA]

PMID:18006644
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.