GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | decreases expression | EXP | | 6480464 | CTD | Curcumin analog results in decreased expression of EGFR mRNA, Curcumin results in decreased expression of EGFR mRNA, Curcumin results in decreased expression of EGFR protein | PMID:15486348, PMID:17918158, PMID:18719366, PMID:26409325 | decreases phosphorylation | EXP | | 6480464 | CTD | Curcumin results in decreased phosphorylation of EGFR protein | PMID:15486348 | multiple interactions | EXP | | 6480464 | CTD | Curcumin inhibits the reaction [Acrylamide results in increased expression of EGFR protein], Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein], Curcumin promotes the reaction [Folfox protocol results in decreased expression of EGFR protein], Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of EGFR protein], Curcumin results in decreased expression of and results in decreased activity of EGFR protein, Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein, Fluorouracil promotes the reaction [Curcumin results in decreased expression of EGFR protein], Fluorouracil promotes the reaction [Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein] | PMID:10851300, PMID:15129424, PMID:17918158, PMID:18214481, PMID:24508477 | decreases expression | ISO | RGD:2543 | 6480464 | CTD | Curcumin results in decreased expression of EGFR mRNA, Curcumin results in decreased expression of EGFR protein | PMID:18332871 | decreases phosphorylation | ISO | RGD:2543 | 6480464 | CTD | Curcumin results in decreased phosphorylation of EGFR protein | PMID:17372590, PMID:18332871 | multiple interactions | ISO | RGD:2543 | 6480464 | CTD | Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA] | PMID:18006644 | | ||||||||||||||||||||||
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