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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1302972
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ehmt2
Name: euchromatic histone lysine methyltransferase 2
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISOCRRD:15501736480464CTDValproic Acid affects the expression of EHMT2 mRNA

PMID:17963808
decreases expressionISOCRRD:16057006480464CTDValproic Acid results in decreased expression of EHMT2 mRNA

PMID:19101580, PMID:23179753, PMID:26272509, PMID:28001369
increases methylationISOCRRD:16057006480464CTDValproic Acid results in increased methylation of EHMT2 gene

PMID:29154799
multiple interactionsISOCRRD:16057006480464CTD[Hydralazine co-treated with Valproic Acid] results in increased expression of EHMT2 mRNA

PMID:17183730
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.